کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375770 | 981944 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12′S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-κB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-κB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.
■■■Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 8, 15 April 2008, Pages 2619–2623
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 8, 15 April 2008, Pages 2619–2623
نویسندگان
Cheng-Zhu Wu, Seong Su Hong, Xing Fu Cai, Nguyen Tien Dat, Ji-Xing Nan, Bang Yeon Hwang, Jung Joon Lee, Dongho Lee,