کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375862 981946 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase
چکیده انگلیسی

A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.

The SAR of a series of quinoxaline inhibitors of c-Met kinase is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 2, 15 January 2009, Pages 397–400
نویسندگان
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