New inhibitors of rabbit muscle triose-phosphate isomerase

We describe the synthesis and evaluation of three new competitive inhibitors of triose-phosphate isomerase. One of them (phosphoglycoloamidoxime: Ki = 4.5 μM) is among the best reversible inhibitors so far reported for this enzyme.

We describe the synthesis and evaluation of three new competitive inhibitors of triose-phosphate isomerase. One of them (phosphoglycoloamidoxime 3a: Ki = 4.5 μM) is among the best reversible inhibitors so far reported for this enzyme.Figure optionsDownload as PowerPoint slide