Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones

A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.

The synthesis and structure–activity relationship of a novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors is described.Figure optionsDownload as PowerPoint slide