The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C

Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC50 values of 0.68 and 4.28 μg/ml, respectively.

The new fungal metabolite, trichodermamide C 1 was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC50 values of 0.68 and 4.28 μg/ml, respectively.Figure optionsDownload as PowerPoint slide