کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376643 981962 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potent triazolyl-proline-based inhibitors of HCV NS3 protease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Potent triazolyl-proline-based inhibitors of HCV NS3 protease
چکیده انگلیسی

The design and synthesis of tripeptide-based inhibitors of the HCV NS3 protease containing a novel P2-triazole is described. Replacement of the P2 quinoline with a triazole moiety provided a versatile handle which could be expediently modified to generate a diverse series of inhibitors. Further refinement by the incorporation of an aryl-substituted triazole and replacement of the P1 acid with an acyl sulfonamide ultimately provided inhibitors with interesting cellular activity.

The SAR studies of a series of triazolyl substituted proline as potent inhibitors of the HCV NS3 protease is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 11, 1 June 2008, Pages 3400–3404
نویسندگان
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