کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1377098 981971 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima
چکیده انگلیسی

Two new cyclohexenones (antheminones A and B) and a new cyclohexanone, (antheminone C) along with five known compounds were isolated from the leaves of Anthemis maritima L. The structures were mainly deduced from extensive 1D and 2D NMR spectroscopy and mass spectrometry. The new compounds were tested in vitro for their cytotoxic activity against adherent and non-adherent cancer cell lines. Antheminones A and C exhibited significant antiproliferative activity against leukemia cells with IC50 values ranging from 3.2 to 14 μM.

Three new compounds, antheminones A (1), B (2), and C (3) were isolated from the leaves of Anthemis maritima. These compounds exhibited significant antiproliferative activity against leukemia cells.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 5, 1 March 2008, Pages 1559–1562
نویسندگان
, , , , , ,