کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378281 | 981997 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines](/preview/png/1378281.png)
چکیده انگلیسی
A series of novel zinc(II) phthalocyanines mono-substituted with a 1,3-bis(dimethylamino)-2-propoxy group at the α- or β-position, and the corresponding di-N-methylated derivatives, have been synthesized. All these compounds can generate singlet oxygen effectively and exhibit high in vitro photodynamic activities toward HT29 human colorectal carcinoma cells with IC50 values down to 0.08 μM. The dicationic derivatives have a higher affinity to the cell membrane compared with the non-ionic counterparts.
A novel series of mono-substituted zinc(II) phthalocyanines have been prepared which exhibit a high photodynamic activity against HT29 human colorectal carcinoma cells with IC50 values down to 0.08 μM.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 1073–1077
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 1073–1077
نویسندگان
Pui-Chi Lo, Baozhong Zhao, Wubiao Duan, Wing-Ping Fong, Wing-Hung Ko, Dennis K.P. Ng,