Discovery of novel biaryl heterocyclic EP1 receptor antagonists

We describe the generation of novel EP1 receptor antagonists by investigation of thiophene isosteres. In addition, we disclose preliminary in vitro and in vivo DMPK for selected compounds.

The synthesis and biological activity of a series of novel EP1 receptor antagonists are described. In vitro and in vivo DMPK data are presented for selected compounds.Figure optionsDownload as PowerPoint slide