کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379588 982032 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis
چکیده انگلیسی

A novel diazocan containing dipeptide mimetic was synthesized via reductive N–N bond cleavage of a pyrazolidino-pyrazolidine using Raney-Ni and evaluated as an ICE inhibitor. This versatile 8-membered ring containing scaffold possesses an N-5 ring nitrogen that was used to explore structure-activity relationships in a cell-based assay measuring inhibition of interleukin-1β.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 19, 1 October 2005, Pages 4291–4294
نویسندگان
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