کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1383804 | 1500873 | 2013 | 11 صفحه PDF | دانلود رایگان |
• E. coli O157:H7 Shiga toxin.
• Synthesis of a heterobifunctional ligand for Stx2.
• A Pk trisaccharide terminated by GalNAc.
• Attachment of ligand to a polyacrylamide scaffold.
• Click chemistry.
Hemolytic uremic syndrome is a potentially fatal complication of food poisoning caused by Escherichia coli O157:H7, especially those strains that produce the Stx2 Shiga toxin. Multivalent inhibitors based on the Pk trisaccharide are most effective against Stx1 the less dangerous of the two Shiga toxins. Inhibitors containing a terminal 2-acetamido-2-deoxy-α-d-galactopyranosyl residue in place of the terminal α-d-galactopyranosyl residue of Pk trisaccharide have been shown to exhibit preferential binding to Stx2. A multivalent heterobifunctional Pk analog containing 2-acetamido-2-deoxy-α-d-galactopyranose has been synthesized in a format that facilitates the ablation of toxin activity via supramolecular complex formation between Stx and the endogenous protein, Human serum amyloid P component (HuSAP).
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Journal: Carbohydrate Research - Volume 378, 30 August 2013, Pages 4–14