کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1384010 982385 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NMR structural analysis of epigallocatechin gallate loaded polysaccharide nanoparticles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
NMR structural analysis of epigallocatechin gallate loaded polysaccharide nanoparticles
چکیده انگلیسی

Nuclear magnetic resonance (NMR) spectroscopy has been employed for structural characterization of epigallocatechin gallate loaded maltodextrin/gum arabic nanoparticles (EGCG-MD/GA). Measurements of the nuclear relaxation times (T1) and application of diffusion ordered spectroscopy (DOSY), obtained through pulsed field gradient (PFG) NMR experiments, have been performed to determine the structure of the epigallocatechin gallate–polysaccharide conjugates and to clarify the mechanisms of drug immobilization into the polymer matrix. The results suggest the entrapment of EGCG into the polysaccharide matrix of maltodextrin/gum arabic (MD/GA) and support the potential of these vehicles for their sustained delivery and release.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 82, Issue 3, 15 October 2010, Pages 861–866
نویسندگان
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