Regioselective allylation of cyclomaltoheptaose (β-cyclodextrin) leading to per(2,6-di-O-hydroxypropyl-3-O-methyl)-β-cyclodextrin

► Optimization of selective allylation, allowing us to obtain per(2,6-di-O-allyl)-α,β,γ-cyclodextrins. ► Synthesis and characterization of per(2,6-O-hydroxypropyl-3-O-methyl)-β-CD in three steps. ► Cyclodextrin derivative presenting seven primary hydroxyl functions on each side of the truncated cone, with symmetric structure.