Preparation of 6-azafulleroid-6-deoxy-2,3-di-O-myristoylcellulose

6-Azafulleroid-6-deoxy-2,3-di-O-myristoylcellulose (3) was synthesized from 6-azido-6-deoxycellulose (1) by two reaction steps. The myristoylation of compound 1 with myristoyl chloride/pyridine proceeded smoothly to give 6-azido-6-deoxy-2,3-di-O-myristoylcellulose (2) in 97.0% yield. The reaction of compound 2 with fullerene (C60) was carried out by microwave heating to afford compound 3 in high yield. It was found from FT-IR, 13C NMR, UV–vis, differential pulse voltammetry (DPV), SEC analyses that compound 3 was the expected C60-containing polymer. Consequently, maximum degree of substitution of C60 (DSC60) of compound 3 was 0.33.

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► We prepared fullerene (C60)-containing cellulose derivative with degree of substitution of C60 of 0.33.
► It was characterized by FT-IR, 13C NMR, UV–vis, DPV, SEC analyses.
► Microwave heating was effective for shortening reaction time.