کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1384639 982412 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A regio- and stereo-controlled approach to triazoloquinoxalinyl C-nucleosides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A regio- and stereo-controlled approach to triazoloquinoxalinyl C-nucleosides
چکیده انگلیسی

The synthesis of a new series of acyclic triazoloquinoxalinyl C-nucleosides and their transformation to their cyclic analogs are described following protection, activation, and deprotection with subsequent intramolecular nucleophilic substitution protocol. The antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that 3a and 2b exhibit good activity against Escherichiacoli and Candidaalbicans. On the other hand, the cyclic mesylated C-nucleoside 13 showed activity against the Gram-positive bacteria (Staphylococcusaureus) and antifungal activity against C. albicans.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 345, Issue 17, 22 November 2010, Pages 2474–2484
نویسندگان
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