کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1385352 982442 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complete assignments of the 1H and 13C chemical shifts and JH,H coupling constants in NMR spectra of d-glucopyranose and all d-glucopyranosyl-d-glucopyranosides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Complete assignments of the 1H and 13C chemical shifts and JH,H coupling constants in NMR spectra of d-glucopyranose and all d-glucopyranosyl-d-glucopyranosides
چکیده انگلیسی

Complete assignment of the 1H and 13C NMR spectra of all possible d-glucopyranosyl-d-glucopyranosides was performed and the 1H chemical shifts and proton–proton coupling constants were refined by computational spectral analyses (using PERCH NMR software) until full agreement between the calculated and experimental spectra was achieved. To support the experimental results, the 1H and 13C chemical shifts and the spin–spin coupling constants between the non-hydroxyl protons of α- and β-d-glucopyranose (1a and 1b) were calculated with density functional theory (DFT) methods at the B3LYP/pcJ-2//B3LYP/6-31G(d,p) level of theory. The effects of different glycosidic linkage types and positions on the glucose ring conformations and on the α/β-ratio of the reducing end hydroxyl groups were investigated. Conformational analyses were also performed for anomerically pure forms of methyl d-glucopyranosides (13a and 13b) and fully protected derivatives such as 1,2,3,4,6-penta-O-acetyl-d-glucopyranoses (14a and 14b).

Computational spectral analyses by simulation and iteration were made to achieve full agreement between experimental and calculated 1H NMR spectra of glucobioses.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 343, Issue 1, 14 January 2008, Pages 101–112
نویسندگان
, , , ,