کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1385442 982446 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Photo-crosslinked glucose-sensitive hydrogels based on methacrylate modified dextran–concanavalin A and PEG dimethacrylate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Photo-crosslinked glucose-sensitive hydrogels based on methacrylate modified dextran–concanavalin A and PEG dimethacrylate
چکیده انگلیسی

A series of glucose-sensitive hydrogels based on glycidyl methacrylate modified dextran (Dex-G), ethylene glycol acrylate methacrylate modified concanavalin A (Con A–E) and poly (ethylene glycol) dimethacrylate (PEGDMA) were synthesized by photopolymerization. The Dex-G precursor was prepared through ring-opening reaction, while Con A–E was obtained from Michael addition reaction. FT-IR was used to characterize the structures of pre-polymers and hydrogels. The degree of substitution (DS) of Dex-G was confirmed by 1H NMR and the activity of modified Con A was approved by fluorescence spectroscopy. Swelling test, component loss measurement and SEM observation demonstrated that the size of hydrogels changed differently in the medium of different glucose concentrations and the glucose sensitivity was influenced by the content of component, especially PEGDMA. SEM image also displayed that hydrogels had microporous structures. All the results indicated that the hydrogels had glucose-sensitive property and good biocompatibility, which could be prospectively applied as glucose biosensor and intelligent insulin delivery carrier.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 82, Issue 2, 5 September 2010, Pages 412–418
نویسندگان
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