Triterpenoid saponins from the root bark of Schima superba and their cytotoxic activity on B16 melanoma cell line

• The chemical constituents of Schima superba were investigated.
• Eight new oleanane-type triterpenoid saponins, along with eight known triterpenoid saponins, were isolated and identified.
• The cytotoxicity of all compounds against B16 melanoma cells was evaluated.

Eight new oleanane-type triterpenoid saponins, schisusaponins A-H, along with eight known triterpenoid saponins, were isolated from the root bark of Schima superb (Theaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. The cytotoxicity of the new compounds against B16 melanoma cells was assessed. Among the isolated new saponins, schisusaponins C and E showed more potent effects (with IC50 values of 10.08 and 10.89 μM) than vinblastine (with an IC50 value of 19.48 μM).

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