Efficient synthesis of ethisterone glycoconjugate via bis-triazole linkage

• Sugar based triazolyl azido-alcohols were prepared under one pot methodology.
• Syntheses of bis-triazolyl ethisterone glycoconjugates were carried out from sugar based triazolyl azido-alcohols via CuAAC reaction.
• The structures were established by FT-IR, NMR, and HR-MS analyses.

Synthesis of sugar based triazolyl azido-alcohols was accomplished via one pot click reaction of glycosyl alkynes with epichlorohydrin in aqueous medium. All the developed triazolyl azido-alcohols were further utilized for the synthesis of bis-triazolyl ethisterone glycoconjugates using CuAAC reaction. The developed triazole-linked ethisterone glycoconjugates would be crucial in androgen receptor pharmacology and chemical biology.

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