کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1387999 1500869 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phenolic glycosides from Ficus tikoua and their cytotoxic activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Phenolic glycosides from Ficus tikoua and their cytotoxic activities
چکیده انگلیسی


• The rhizomes of Ficus tikoua were phytochemically investigated for the first time.
• The structures of the glycosides were characterised including the determination of absolute configurations of the sugars.
• This cytotoxicity of the isolates provided a scientific support to the previous pharmacological investigation.
• We interpreted the main cytotoxic constituents in this Miao ethnomedicine.

Four new phenolic glycosides, named 2-ethylene-3,5,6-trimethyl-4-phenol-1-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside (1), 3-methoxy-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranosylpropiophenone (2), 3-hydroxy-1-(4-O-β-d-glucopyranosyl-3-methoxyphenyl)propan-1-one (3) and 4-hydroxy-3,5-bis(3′-methyl-2-butenyl)benzoic acid-O-β-d-glucopyranoside (4), were isolated from the ethanol extract of Ficus tikoua, together with six known compounds: 3,4,5-trimethoxyphenol-1-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (5), 3,4,5-trimethoxyphenol-1-O-β-d-glucopyranoside (6), 3-methoxy-4-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranosylpropiophenone (7), baihuaqianhuoside (8), 3,5-dimethoxy-4-hydroxybenzoic acid-O-β-d-glucopyranoside (9) and 2-methoxy-4-allylphenyl-1-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (10). The structures of the four new compounds were elucidated by chemical methods and MS and IR, as well as 1D and 2D NMR analyses. The cytotoxicities of the 10 compounds against HeLa, K562, HL60 and HepG2 cell lines were assessed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 382, 15 December 2013, Pages 19–24
نویسندگان
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