کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1388405 | 1500846 | 2015 | 10 صفحه PDF | دانلود رایگان |
• Cyclopeptides are attractive scaffolds for the preparation of glycostructures.
• Low molecular weight glycoclusters to nano-sized glycodendrimers are described.
• Oxime ligation is a powerful strategy to synthesize a variety of glycostructures.
• Carbohydrate units are displayed with well-defined spatial orientation.
• Relevant recognition properties have been observed with diverse lectins.
Cyclopeptides have recently emerged as attractive molecular scaffolds for the multivalent presentation of carbohydrates in a well-defined constrained spatial orientation. This mini-review describes the last advances on the synthesis and the biological applications of these particular structures, going from low molecular weight glycoclusters to fully synthetic nano-sized glycodendrimers.
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Journal: Carbohydrate Research - Volume 405, 20 March 2015, Pages 13–22