Synthesis of a fluorescence-labeled K30 antigen repeating unit using click chemistry

An N-dansyl-labeled K30 antigen repeating unit, {4-[5-(N,N′-dimethylamino)naphthalene-1-sulfonamine]-1H-1,2,3-triazol-1-yl}hexyl β-d-glucopyranosyluronate-(1→3)-α-d-galactopyranosyl-α-d-mannopyranosyl-(1→3)-β-d-galactopyranoside, was synthesized using click chemistry, the copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of an azide and an alkyne. The target compound could further facilitate the studies of interactions among K30 oligosaccharides and proteins.

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