کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1389859 | 982933 | 2007 | 7 صفحه PDF | دانلود رایگان |
A glyconucleoside containing a thioglycoside linkage, namely 1-(3-S-β-d-ribofuranosyl-2,3-dideoxy-3-thio-β-d-ribofuranosyl)-thymine, has been prepared through condensation of a suitably protected derivative of 3′-thiothymidine with an activated ribose sugar. NMR has been used to study the conformation of the S-disaccharide and the unmodified O-disaccharide. A full pseudorotational analysis showed that for the S-disaccharide, the ribose and deoxy ribose sugars have a preference for the south and north pucker, respectively; which is the reverse of what is seen for the O-disaccharide.
NMR studies have revealed that the conformational preferences of both furanose sugars in a glyconucleoside are altered by the incorporation of a thioglycoside linkage.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 342, Issue 1, 15 January 2007, Pages 16–22