کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1390430 | 983073 | 2011 | 6 صفحه PDF | دانلود رایگان |
Here we report the structural characterization, physicochemical study and molecular modeling of the inclusion complex of trimethoprim in randomly methylated beta-cyclodextrin. The phase-solubility diagram obtained at pH 7.0 exhibited a linear behavior for the RAMEB concentrations studied suggesting a 1:1 stoichiometry and absence of aggregation in solution. From stoichiometric determination by the continuous variation method we confirmed a 1:1 stoichiometry. To make a detailed characterization of the inclusion mode, spectroscopic measurements by infrared and 1D and 2D 1H NMR spectroscopy provided evidence that the inclusion mode is characterized by inclusion of the trimethoxyphenyl ring in the cavity; interactions with methyl groups located in the border of the cavity were also detected. The structure proposed was also confirmed by semiempirical molecular modeling.
An inclusion complex of trimethoprim and randomly methylated β-cyclodextrin was prepared and characterized, evidencing the inclusion of the trimethoxyphenyl ring, in agreement with semiempirical molecular modeling.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 346, Issue 17, 13 December 2011, Pages 2746–2751