کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390650 983117 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines
چکیده انگلیسی

Cyclization by double reductive amination of d-xylo-hexos-5-ulose with methyl 6-aminohexanoate gave (methoxycarbonyl)pentyl-1-deoxynojirimycin. Reaction of the terminal carboxylic acid with N-dansyl-1,6-diaminohexane provided the corresponding chain-extended fluorescent derivative. By reaction with bis(6-dansylaminohexyl)amine, the corresponding branched di-N-dansyl compound was obtained. Both compounds are strong inhibitors of d-glucosidases and could also be shown to distinctly improve, at sub-inhibitory concentrations, the activity of β-glucocerebrosidase in a Gaucher fibroblast (N370S) cell-line through chaperoning of the enzyme to the lysosome.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 345, Issue 10, 2 July 2010, Pages 1371–1376
نویسندگان
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