کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390702 983127 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Supramolecular hydrogels formed from biodegradable ternary COS-g-PCL-b-MPEG copolymer with α-cyclodextrin and their drug release
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Supramolecular hydrogels formed from biodegradable ternary COS-g-PCL-b-MPEG copolymer with α-cyclodextrin and their drug release
چکیده انگلیسی

On the basis of the synthesis of novel biodegradable amphiphilic MPEG-b-PCL-grafted chitooligosaccharide (COS-g-PCL-b-MPEG) copolymers, supramolecular hydrogels were fabricated rapidly via their inclusion complexation with α-cyclodextrin (α-CD) in aqueous solutions. The graft copolymers were characterized by 1H NMR spectroscopy, gel permeation chromatography (GPC), and fluorescence measurement, and the supramolecular structure of the resultant hydrogels was confirmed by X-ray diffraction measurements. Rheological studies of as-obtained hydrogels indicate that the physical properties could be modulated by controlling the concentration and the graft content of the graft copolymers as well as the molar feed ratio of the graft to α-CD. The in vitro release kinetics studies of bovine serum albumin (BSA) entrapped in the hydrogels show that the drug release profiles are dependent on the supramolecular hydrogel compositions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 344, Issue 16, 2 November 2009, Pages 2201–2208
نویسندگان
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