کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390838 1500905 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of a bicyclic analog of l-iduronic acid adopting the biologically relevant 2S0 conformation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of a bicyclic analog of l-iduronic acid adopting the biologically relevant 2S0 conformation
چکیده انگلیسی

The synthesis of a bicyclic analogue of the naturally occurring α-l-iduronic acid locked in a biologically active 2S0 skewboat conformation is disclosed. The desired 2S0 conformation has been obtained by tethering the C-2 and C-5 carbon atoms of the sugar ring with a dimethyloxy bridge and confirmed by NMR and molecular modeling. The new mimic displays the exact hydroxyl pattern of α-l-iduronic acid, a major monosaccharide component of glycosaminoglycans and thus represents a closer mimic of the latter, compared to previously reported bicyclic analogs.Figure optionsDownload as PowerPoint slide

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 342, Issues 12–13, 3 September 2007, Pages 1876–1887
نویسندگان
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