کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1394697 | 1501363 | 2015 | 18 صفحه PDF | دانلود رایگان |
• We report common cross-linking techniques for fabrication of injectable hydrogels.
• Synthesis, materials, properties and activities of such hydrogels are presented.
• Particular attention in therapeutic agent delivery applications is given.
Since drug delivery systems have become one of the most promising areas of human health related research, the applications of biomaterials such as hydrogels have been widely investigated. Possessing unique hydrophilic, biocompatible network structures and the ability to form solid-like gel states once administered, injectable hydrogels facilitate the encapsulation and release of therapeutic agents, including drugs, proteins, genes and cells, in a controllable manner. A wide and diverse range of techniques have been used to generate hydrogels, from chemical cross-linking, such as photo-polymerization, click chemistry, enzyme-catalyzed reactions, Schiff’s base reactions, and thiol-based Michael reactions, to physical cross-linking induced by temperature, pH, ionic interaction, guest–host inclusion, stereo-complexation or complementary binding. This review covers the utilization of various injectable hydrogel systems for the delivery of therapeutic agents from the viewpoint of cross-linking methods.
Figure optionsDownload as PowerPoint slide
Journal: European Polymer Journal - Volume 72, November 2015, Pages 602–619