Hansen solubility parameters of polyglycolic acid and interaction parameters between polyglycolic acid and solvents

• The solubility parameters of PGA were acquired by optimization calculation.
• The solubility parameters of PGA were verified to be reliable by other methods.
• The values of χ12 and Ri were reported for PGA for the first time.
• The results of χ12 are consistent with Flory–Huggins theory.

This article focuses on the solubility parameters and interaction parameters of polyglycolic acid. 43 solvents have been used for polyglycolic acid to study the dissolution property. Then the Hansen three-dimensional solubility parameters and total parameter of polyglycolic acid were obtained by an optimization calculation. The values of δd, δp, δh and δ for polyglycolic acid have been obtained as 17.094 (J/cm3)1/2, 8.206 (J/cm3)1/2, 7.912 (J/cm3)1/2 and 20.546 (J/cm3)1/2. It was proved that the total parameter of polyglycolic acid is creditable by intrinsic viscosity approach and group contribution method. The values of the interaction parameter and the solubility parameter “distance” between polyglycolic acid and 43 solvents have been calculated. The results of the interaction parameters accords well with the standard of complete miscibility suggested by Flory–Huggins for polymers and solvents.

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