کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395423 1501372 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermo- and pH-sensitive hydrogels functionalized with thiol groups
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Thermo- and pH-sensitive hydrogels functionalized with thiol groups
چکیده انگلیسی


• Synthesis of thiolated hydrogels by free radical polymerization is reported.
• A new methacrylic monomer (AcSEMA) with thiol protected group was used.
• Thermo-responsive polymers were obtained by copolymerization with MEO2MA.
• After deprotection of thiol groups polymers also showed remarkable pH sensitivity.

Tacking into account the great potential of hydrogels bearing thiol functionalities, in this work we report the synthesis of thiolated hydrogels by free radical polymerization of (i) a thermo-responsive monomer, 2-(2-methoxyethoxy)ethyl methacrylate (MEO2MA); (ii) a lower ratio of a monomer having protected thiol group, 2-(acetylthio)ethyl methacrylate (AcSEMA) and (iii) a small proportion of tetraethylene glycol dimethacrylate (TEGDMA) as crosslinker. Subsequently, deprotection of thioacetate groups, by incubating the samples in basic solutions, allows obtaining hydrogels with free thiol groups. After this treatment, the pH dependence of the thiol–thiolate equilibrium makes the thermal response of novel P(MEO2MA-co-SEMA) strongly modulated by the pH.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Polymer Journal - Volume 63, February 2015, Pages 37–44
نویسندگان
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