کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395884 984142 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Label-free DNA sensor construction using self-assembled poly(o-methoxyaniline) hollow nanospheres
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Label-free DNA sensor construction using self-assembled poly(o-methoxyaniline) hollow nanospheres
چکیده انگلیسی

Poly(o-methoxyaniline) (POMA) hollow nanospheres diameter in 210 nm were prepared in a solution of poly(methyl vinyl etheralt-maleic acid) (PMVEA) by a self-assembly process using ammonium persulfate (APS) as the oxidant. The morphology and the amount of nanospheres of POMA in the final products are highly affected by the molar ratio of APS to o-methoxyaniline (OMA) and the concentration of OMA. The structure and property of POMA hollow nanospheres were characterized by FTIR and cyclic voltammetry. We constructed a label-free oligonucleotide (ODN) sensor using PMVEA-doped POMA nanospheres: PMVEA provides a high density of carboxylic acid groups for covalent grafting of the ODN probe. The hybridization of the complementary ODNs can be clearly detected by the decrease in the impedance without the need for an indicator or any sample modifications.

Poly(o-methoxyaniline) hollow nanospheres were prepared in a solution of poly(methyl vinyl etheralt-maleic acid).Figure optionsDownload as PowerPoint slideHighlights
► POMA/PMVEA hollow nanospheres with higher conductivity have been synthesized.
► We constructed a label-free oligonucleotide (ODN) sensor using POMA/PMVEA nanospheres.
► Hybridization of the complementary ODNs can be detected by the impedance decrease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Polymer Journal - Volume 49, Issue 1, January 2013, Pages 139–146
نویسندگان
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