Photoinitiated synthesis of multi-sensitive micelles for drug release

• 2-Ketobutyric acid (2-KBA) was used as photoinitiator and emulsifier.
• Multi-sensitive micelles with core and shell structure were prepared.
• The micelles exhibited temperature, glucose concentration and pH sensitivity.
• The work provides a new platform for development drug delivery vehicles.

The multi-sensitive micelles were prepared through a photoinitiated polymerization and self-assembly route using 2-ketobutyric acid (2-KBA) as effective water-soluble photoinitiator and emulsifier. The drug release behaviors were investigated under different glucose concentration, pH and temperature conditions. This work provides a new platform for development drug delivery vehicles with reducing possible utilization of organic solvents and initiators and surfactants.

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