کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1400388 1501362 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and characterization of chitosan-lactate–phthalate and evaluation of the corresponding zinc- and aluminum-crosslinked beads as potential controlled release matrices
ترجمه فارسی عنوان
سنتز و مشخص کردن کیتوزان-لاکتاتا فتالات و ارزیابی دانه های متقابل روی و آلومینیوم به عنوان ماتریس آزاد شدن کنترل به صورت بالقوه
کلمات کلیدی
فتالات لاکتات کیتوزان، منجوق، پیوند یونیک، فنوباربیتون، انتشار کنترل شده
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Chitosan-lactate–phthalate polymeric conjugates were synthesized.
• The polymeric conjugates were characterized by infrared spectroscopy and differential scanning calorimetry.
• The polymeric conjugates were used to prepare zinc- and aluminum-crosslinked beads loaded with phenobarbitone.
• The resulting beads were characterized by scanning electron microscopy.
• The metal-crosslinked beads were evaluated as controlled release vehicles for the delivery of phenobarbitone as model drug.

New semisynthetic chitosan derivatives were prepared by grafting chitosan with lactate and phthalate substituents. The resulting polymers were successfully employed in the formation of polymeric beads by facile ionotropic crosslinking with zinc or aluminum ions. Ionic crosslinking was confirmed by infrared spectroscopy and differential scanning calorimetry. The produced beads were loaded with phenobarbitone (PhB) as a model drug and evaluated as potential controlled release matrices. Interestingly, the loaded beads illustrated pH-dependent release profiles with enteric properties and prolonged release under simulated intestinal fluids. The newly modified polymers offer attractive alternatives for the conventional chitosan polymers especially for oral delivery and help to overcome some of their drawbacks in controlling drug release.

Metal crosslinking of chitosan phthalate and chitosan lactate phthalate with zinc and aluminum metal ions.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Polymer Journal - Volume 73, December 2015, Pages 402–412
نویسندگان
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