Synthesis, structural characterization and biological studies of copper complexes with 2-aminobenzothiazole derivatives

• A series of novel copper complexes of 2-aminobanzothiazole derivatives were synthesized.
• A potent lead compound by selecting suitably substituted Knoevenagal moiety.
• Six compounds with high potency and better antioxidant agents.

Novel copper complexes of 2-aminobenzothiazole derivatives were synthesized by the condensation of Knoevenagel condensate acetoacetanilide (obtained from substituted benzaldehydes and acetoacetanilide) and 2-aminobenzothiazole. They were thoroughly characterized by elemental analysis, IR, 1H NMR, UV–Vis., MS Spectra, molar conductance, magnetic moment and electrochemical studies. These spectral studies suggested that distorted square planar geometry for all the complexes. Molar conductance data and magnetic susceptibility measurements provide evidence for monomeric and neutral nature of the complexes. The electrochemical behaviour of the ligand and complexes in DMSO at 298 K was studied. The present ligand systems stabilize the unusual oxidation states of copper ion during electrolysis. Antibacterial screening of the ligands and their complexes reveal that all the complexes show higher activities than the free ligands.

Novel copper complexes of 2-aminobenzothiazole derivatives were synthesized by the condensation of knoevenagal condensate acetoacetanilide (obtained from substituted benzaldehydes and acetoacetanilide) and 2-aminobenzothiazole. They were thoroughly characterized by elemental analysis, IR, 1H NMR, UV–Vis., molar conductance, magnetic moment and electrochemical studies.Figure optionsDownload as PowerPoint slide