کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1402730 984782 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel interpenetrating smart polymer networks grafted onto polypropylene by gamma radiation for loading and delivery of vancomycin
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel interpenetrating smart polymer networks grafted onto polypropylene by gamma radiation for loading and delivery of vancomycin
چکیده انگلیسی

Gamma radiation was used in every step of the synthesis of a sequential interpenetrating polymer network made of two “smart” polymers: poly(acrylic acid) (PAAc) and poly (N-isopropylacrylamide) (PNIPAAm), the latter grafted onto polypropylene (PP) films (PP-g-PNIPAAm) with the aim of developing medicated coatings for medical devices. Three steps were followed for obtaining net-PP-g-PNIPAAm-inter-net-PAAc: graft copolymerization of PNIPAAm onto PP films by gamma pre-irradiation oxidative method, cross-linking of PP-g-PNIPAAm by gamma irradiation in water to form the first network, with or without N,N′-methylenebis(acrylamide) (MBAAm), and finally the formation of the second network through the polymerization and cross-linking of AAc inside cross-linked PP-g-PNIPAAm by a low gamma radiation dose of 2.5 kGy. The films were characterized regarding the amount of grafted polymers and their composition (FTIR-ATR), thermal behavior (DSC), temperature- and pH-responsive swelling and contact angle (critical pH 6 and lower critical solution temperature ∼33 °C), and loading and release rate of vancomycin. Drug loading was driven by specific interactions between vancomycin and PAAc. Drug-loaded films sustained the delivery for several hours at pH 7.4 and provided release rate values adequate for killing bacteria attempting to adhere the surface of the films.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Polymer Journal - Volume 45, Issue 7, July 2009, Pages 1859–1867
نویسندگان
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