کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1403258 | 1501780 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A new copper(II) complex with 2-thenoyltrifluoroacetone and 2,2-bipyridine: Crystal structure, spectral properties and cytotoxic activity A new copper(II) complex with 2-thenoyltrifluoroacetone and 2,2-bipyridine: Crystal structure, spectral properties and cytotoxic activity](/preview/png/1403258.png)
This work reports the synthesis and characterization of a new copper(II) complex with 2-thenoyltrifluoroacetone (HTTA) and 2,2-bipyridine (bipy). The complex was characterized by elemental analysis, UV–Vis, IR and EPR. The crystal structure was determined by single-crystal X-ray diffraction. The copper ion has a distorted square-pyramidal geometry and is coordinated to two bidentate ligands (HTTA and bipy) and a perchlorate ion weakly bonded in the apical position. The crystal packing is stabilized by non-classical hydrogen bonds and weak interactions π–π stacking. In the copper complex, the metal ion binds to HTTA via the oxygen atoms of the β-diketone group and to bipy via its two heterocyclic nitrogens. The title compound inhibits the growth of K562 cells with an IC50 value equal to 28.2 μmol L−1.
► A new copper(II) complex with 2-thenoyltrifluoroacetone and 2,2-bipyridine was obtained.
► The crystal structure was determined by single-crystal X-ray diffraction.
► The crystal packing is stabilized by non-classical hydrogen bonds and weak interactions π–π stacking.
► The copper complex inhibits the growth of K562 cells with an IC50 value equal to 28.2 μmol L−1.
Journal: Journal of Molecular Structure - Volume 1034, 27 February 2013, Pages 84–88