Spectroscopic, semiempirical studies and antibacterial activity of new urethane derivatives of natural polyether antibiotic - Monensin A

► Two molecules of ionophore antibiotic - Monensin A are connected by different diurethane linkers. ► Structure of new compounds was determined using spectroscopic and semiempirical methods. ► Antimicrobial activity of Monensin derivatives were tested. ► Compounds show activity against Gram-positive bacteria and methicillin-resistant Staphylococcus aureus.