کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1403716 1501809 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, supramolecularity and in vitro antimicrobial activity of 3a,8a-dihydroxy-2-thioxo-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazol-8(2H)-one
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, supramolecularity and in vitro antimicrobial activity of 3a,8a-dihydroxy-2-thioxo-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazol-8(2H)-one
چکیده انگلیسی

The solid-state structure of 3a,8a-dihydroxy-2-thioxo-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazol-8(2H)-one (3) was determined using X-ray single crystal technique. Its non-covalent interactions were analyzed carefully in terms of crystal engineering and supramolecular chemistry. Multiple sulfur–hydrogen and oxygen–hydrogen interactions are present in the structure, most commonly involving bifurcated H⋯S⋯H motifs which resulted in formation interesting centrosymmetric dimmers. This compound demonstrated comparable antimicrobial activity to that of clinically used antimicrobial agents against selected microorganisms.


► A 1:1 adduct (3) has been synthesized in 100% yield by the reaction of ninhydrin with thiourea.
► The structure was assigned on the basis of spectral analysis and single crystal X-ray analysis.
► O, S and N cause interesting intermolecular non-covalent interactions in its solid-state motifs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1005, Issues 1–3, 16 November 2011, Pages 152–155
نویسندگان
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