کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1404023 | 1501848 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Absolute configuration of neostenine Absolute configuration of neostenine](/preview/png/1404023.png)
Heavy atoms bromine and iodine were incorporated into the neostenine (1) skeleton through reductive cleavage of the lactone ring, followed by acylation with 4-bromobenzoyl chloride, and salt formation with methyl iodide, respectively. The absolute configuration of the seven chiral centers C1, C9, C9a, C10, C11, C1 and C13 in 1 were assigned as S, S, R, R, R, R, and S, respectively, based on the Flack parameters in X-ray structure refinement, and results from the two heavy atom derivatives are consistent with each other. As many Stemona alkaloids share the same lactone and pyrrolo[1,2-α]azepine nucleus as those in 1, the facile method reported in this paper can be applied for the determination of absolute configurations of similar alkaloids.
Journal: Journal of Molecular Structure - Volume 966, Issues 1–3, 11 March 2010, Pages 18–22