کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1404695 1501921 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrogen bonding in molecular recognition by HIV-1 protease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hydrogen bonding in molecular recognition by HIV-1 protease
چکیده انگلیسی
Molecular recognition of the cleavage sites of the substrates by HIV-1 protease is analyzed in terms of hydrogen bonding. Crystal structures of an inactive enzyme complexed with six different substrates were used as reference structures. Applying molecular mechanics calculations it can be shown that the interaction energies between the real substrate and the enzyme are larger than with other peptides. From the analysis, it can be concluded that water molecules are essential in the recognition process. Moreover, the hydrogen bonds between the protease and various substrates are characterized in detail.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 790, Issues 1–3, 5 June 2006, Pages 174-182
نویسندگان
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