Synthesis, characterization, crystal structures, computational studies, and antibacterial activities of two new Schiff bases derived from isophthalaldehyde

• The new compounds showed moderate antibacterial activity.
• The crystal structures were determined by X-ray diffraction.
• Molecular orbital calculations were performed.
• Complexes have been characterized by the analytical and spectral methods.

Two new Schiff bases, N,N′-(1,3-phenylenebis(methanylylidene))bis(4-bromoaniline) (1) and N,N′-(1,3-phenylenebis(methanylylidene))bis(4-methoxyaniline) (2), have been synthesized by the reaction between isophthalaldehyde and appropriate aniline derivatives, and characterized by physico-chemical and spectroscopic methods. The structures of new compounds 1 and 2 have been characterized crystallographically. Moreover, structural optimization by DFT calculations have been performed and compared with the experimental data. The compounds were also screened for in vitro antibacterial activities against four human pathogenic bacteria and their minimum inhibitory concentrations showed moderate antibacterial activities.

Two new Schiff bases have been synthesized by the reaction between isophthalaldehyde and appropriate aniline derivatives, and characterized by various Spectroscopic techniques. The crystal structures of 1 and 2 were determined by X-ray diffraction. Moreover, structural optimization by DFT calculations have been performed and compared with the experimental data. The compounds were also screened for in vitro antibacterial activities against four human pathogenic bacteria and their minimum inhibitory concentrations showed moderate antibacterial activities.Figure optionsDownload as PowerPoint slide