Host–guest interaction between pinocembrin and cyclodextrins: Characterization, solubilization and stability

• A series of novel pinocembrin/CD inclusion complexes was prepared.
• The inclusion behavior and characterization of pinocembrin with CD were investigated.
• The water solubility of pinocembrin was obviously increased in inclusion complexes.
• The pinocembrin/CD complexes are much more stable than free pinocembrin.

The inclusion complexation behavior, characterization and binding ability of pinocembrin with β-cyclodextrin (β-CD) and its derivative 2-hydroxypropyl-β-cyclodextrin (HPβCD) were investigated in both solution and the solid state by means of XRD, DSC, 1H and 2D NMR and UV–vis spectroscopy. The results showed that the water solubility and thermal stability of pinocembrin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high stability of the pinocembrin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.

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