Growth, characterization and crystal structure analysis of rifapentine

Single crystals of rifapentine have been grown by cooling technique. The crystal structure analysis and the molecular arrangement of these crystals have been determined using X-ray diffraction (XRD) method. From single-crystal XRD studies, it is found that the compound crystallizes in the monoclinic system with a space group P21, and the corresponding lattice parameters were calculated (a = 12.278(3) Å, b = 19.768(4) Å, c = 12.473(3) Å, Z = 2, beta = 112.35(3)°). FT-IR spectra are recorded to identify the various functional groups present in the compound. The UV–Vis spectrum of rifapentine takes place at a wavelength of 236, 255, 334 and 474 nm, respectively. The thermal stability of the crystal is determined from TG/DTA curves.