کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1406803 1501872 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conformation and conformational exchange of Olopatadine hydrochloride
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Conformation and conformational exchange of Olopatadine hydrochloride
چکیده انگلیسی

Besides the assignments of the 13C and 1H shifts by 1D and 2D NMR, the experiment 1H spectra of Olopatadine hydrochloride were recorded at temperature range 228–338 K. The variable-temperature spectra revealed a dynamic NMR effect which is attributed to conformational interconversion of the drug. At low temperature, the solution was shown to contain two conformers and the ration of them was 1:1. A conformational process with a free energy of activation of 56.7 kJ mol−1, coalescence temperature 298 K, was interpreted as geminal 1H exchange. Using molecule simulation, conformational candidates for two conformers are proposed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 892, Issues 1–3, 15 December 2008, Pages 398–401
نویسندگان
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