کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1406888 | 1501876 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Unusual effect of bulky isopropyl group on robustness of the U-motif in pyrazolo[3,4-d]pyrimidine core based 'Leonard linker' compounds in comparison to methyl/ethyl group: A1H NMR and X-ray crystallographic study
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
X-ray crystallographic analysis of new symmetrical 'Leonard/trimethylene linker' isopropyl analog 1,3-bis(4-isopropoxy-6-methylsulfonyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propane (1h) does not show chain motif formed due to intermolecular CHâ¦O interactions between O atoms of sulfonyl groups and central methylene H atoms of linker along with CHâ¦N interactions or plus (+) motif shown earlier by corresponding methyl- (1f) and ethyl- (1g) analogs. More importantly, the more or less superimposed U-motif conformation of 1h is very different from earlier related 10 symmetrical compounds (1a-1g & 2). In 1h intramolecular folding is in such a way that whole pyrazolo[3,4-d]pyrimidine core of one side stacks more or less face-to-face on opposite side of the same molecule while in earlier compounds (1a-1g & 2) there is no intramolecular stacking between pyrazolo portions and only pyrimidine portions partially stack with each other. Surprisingly, ethyl analog (1i) of 1h again shows U-motif conformation similar to earlier related ten symmetrical compounds (1a-1g & 2). Supramolecular structures of both compounds (1h & 1i) are stabilized by weak intermolecular CHâ¦O, CHâ¦N and Ï-Ï interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 888, Issues 1â3, 15 October 2008, Pages 327-336
Journal: Journal of Molecular Structure - Volume 888, Issues 1â3, 15 October 2008, Pages 327-336
نویسندگان
Kamlakar Avasthi, Sangeeta Aswal, Sheikh M. Farooq, Resmi Raghunandan, Prakas R. Maulik,