کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1407033 1501871 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of a new foldamer turn-linker-turn in acyclic hexapeptides and formation of channels through self-assembly
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design of a new foldamer turn-linker-turn in acyclic hexapeptides and formation of channels through self-assembly
چکیده انگلیسی
Single crystal X-ray diffraction studies and solvent dependent NMR titration reveal that the designed peptides I and II, Boc-Xx(1)-Aib(2)-Yy(3)-NH(CH2)2NH-Yy(3)-Aib(2)-Xx(1)-Boc, where Xx and Yy are Ile and Leu in peptide I and Leu and Val in peptide II, respectively, fold into a turn-linker-turn (T-L-T) conformation both in the solid state and in solution. In the crystalline state the T-L-T foldamers of peptide I and II self-assemble to form a three-dimensional framework of channels. The insides of the channels are hydrophilic and found to contain solvent CHCl3 hydrogen bonded to exposed CO of Aib located at the turn regions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 917, Issues 2–3, 15 January 2009, Pages 110-116
نویسندگان
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