Comparison of structure in solid state of new 1,5-bis(4-cyano-2,6-dimethoxyphenoxy)alkanes by means of 13C CP/MAS NMR and X-ray diffraction

The synthesis and structural studies in solid state of new 1,5-bis(4-cyano-2,6-dimethoxyphenoxy)-3-oxapentane 1 and 1,5-bis(4-cyano-2,6-methoxyphenoxy)pentane 2 are presented. The observed complicated network of intermolecular interaction with participation of nitrile groups could play a role in their interaction with the biological target. In vitro screen against 60 human tumor cell lines revealed that compound 1 has promising growth inhibitory power GI50 against SR (leukemia) and HOP-92 (non-small lung cancer) equal to 4.33×10−6 and 1.03×10−5 M, respectively.