کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1407418 | 1501906 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Is planarity of pyridin-2-yl- and pyrazin-2-yl-formamide thiosemicarbazones related to their tuberculostatic activity? X-ray structures of two pyrazine-2-carboxamide-Nâ²-carbonothioyl-hydrazones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Crystal structures of two title compounds and several their relatives known earlier reveal conservative and characteristic features, which may be related to their tuberculostatic activity. The molecules are predominantly planar due to conjugation through five successive bonds in the zwitterionic fragment Sâ-C(sp2)-N-NH+-C(sp2)-NH2 and intramolecular hydrogen bonds, which prevent rotation of the adjacent pyrazine (or pyridine) ring. It has been suggested that in spatial sense such planar molecules resemble acridines intercalating with nucleic acids and that similar process may be responsible for tuberculostatic activity of the title pyrazine-2-carboxamide-Nâ²-carbonothioyl-hydrazones.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 830, Issues 1â3, 30 March 2007, Pages 171-175
Journal: Journal of Molecular Structure - Volume 830, Issues 1â3, 30 March 2007, Pages 171-175
نویسندگان
Andrzej Olczak, Marek L. GÅówka, Jolanta GoÅka, MaÅgorzata Szczesio, Joanna Bojarska, Krystyna KozÅowska, Henryk Foks, CzesÅawa Orlewska,