Structural consistency analysis of recombinant and wild-type human serum albumin

The figure shows 3D structures of rHSA(A), HSA (B) and superimposed contrast result(C). The superimposed contrasted analysis indicated that rHSA and HSA achieved a structural similarity of 99% with an r.m.s. deviation of 0.397 Å for the corresponding overall Cα atoms. The analysis results indicated that 3D structures of rHSA and HSA were virtually identical and rHSA can potentially replace HSA. The study provides a theoretical and experimental basis for rHSA applications.