کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1408334 | 1501736 | 2015 | 7 صفحه PDF | دانلود رایگان |
• A polypeptide-based brush composed of polypeptide backbone and oligo (ethylene glycol) side chains was effectively synthesized.
• The α-helix of the polypeptides showed reversible changes upon heating in water.
• The self-assembly micelles formed by the brush is thermo-sensitive in water.
A new polypeptide-based copolymer brush composed of poly (γ-propargyl-L-glutamate)-block-poly (propylene oxide)-block-poly (γ-propargyl-L-glutamate) backbone (PPLG-b-PPO-b-PPLG) and oligo (ethylene glycol) (PEG) side-chain was synthesized by combination of N-carboxyanhydride ring-opening polymerization and click chemistry. Nearly 100% grafting efficiency was achieved by copper-catalyzed azide-alkyne Huisgen 1,3-dipolar cycloaddition (CuAAc) reaction. The α-helical conformation adopted by the grafted polypeptide blocks in water was relatively stable and showed a reversible change in a heating–cooling circle from 5 to 70 °C. It displayed weak stability against elevated temperature but still reversible changes in the presence of 0.47 M NaCl. The brushes were amphiphilic and could self-assemble into thermo-sensitive micelles in water. Big micelles could break into small micelles upon heating due to the improved solubility.
The conformation dependance of polypeptide blocks on temperature.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Structure - Volume 1081, 5 February 2015, Pages 274–280